Of MAK are going to be performed to isolate and characterize the active ingredients responsible for these antidepressant-like effects.Abbreviations 5-HT: 5-hydroxytryptamine (serotonin); 5-HTP: 5-hydroxytryptophan; DOI: (?-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride; MAK: A water-soluble extract from the culture medium of Ganoderma lucidum mycelia; SSRIs: Selective serotonin reuptake inhibitors; SNRIs: Serotonin and noradrenaline reuptake inhibitors; TCAs: Tricyclic antidepressants. Competing interests The authors declare that they have no competing interests. Authors’ contributions MO and YH conceived the project and supervised the study. HM created the experimental protocol, carried out the behavioral tests with YS, analyzed the information, and wrote the first draft of the manuscript. NI and SK helped to create the protocol and analyze the data. FS and HI prepared a water-soluble extract from the culture medium of Ganoderma lucidum mycelia. MO evaluated the results and wrote the final draft of this manuscript. All the authors have authorized the final manuscript. Author information 1 Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan. 2Laboratory of Immunobiochemistry, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan. 3Noda Shokukin-kogyo Co. Ltd.; 295 Nanakodai, Noda, Chiba 278-0051, Japan. Received: 15 October 2012 Accepted: 19 December 2013 Published: 26 December 2013 References 1. Charney DS: Monoamine dysfunction and also the pathophysiology and treatment of depression. J Clin Psychiatry 1998, 59(Suppl 1):11?four. 2. Papakostas GI: Tolerability of modern antidepressants. J Clin Psychiatry 2008, 69(Suppl E):8?three. three. Xu C, Teng J, Chen W, Ge Q, Yang Z, Yu C, Yang Z, Jia W: 20(S)-protopanaxadiol, an active ginseng metabolite, exhibits sturdy antidepressant-like effects in animal tests. Prog Neuropsychopharmacol Biol Psychiatry 2010, 34:1402?411. four. Singh GK, Garabadu D, Muruganandam AV, Joshi VK, Krishnamurthy S: Antidepressant activity of Asparagus racemosus in rodent models.1443380-14-0 manufacturer Pharmacol Biochem Behav 2009, 91:283?90.Price of Methyl 6-(chloromethyl)picolinate five.PMID:24025603 Machado DG, Bettio LEB, Cunha MP, Capra JC, Dalmarco JB, Pizzolatti MG, Rodrigues ALS: Antidepressant-like impact of the extract of Rosmarinus officinalis in mice: involvement of the monoaminergic method. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33:642?50. six. Grundmann OLVY, Kelber O, Butterweck V: Mechanism of St. John’s wort extract (STW3-VI) throughout chronic restraint pressure is mediated by the interrelationship from the immune, oxidative defense, and neuroendocrine method. Neuropharmacology 2010, 58:767?73. 7. Sanodiya B, Thakur G, Baghel R, Prasad G, Bisen P: Ganoderma lucidum: a potent pharmacological macrofungus. Curr Pharm Biotechnol 2009, ten:717?42.10.11.12.13.14.15.16. 17.18.19.20.21. 22.23.24.25.26.27.28.29.Lu H, Uesaka T, Katoh O, Kyo E, Watanabe H: Prevention of the development of preneoplastic lesions, aberrant crypt foci, by a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male F344 rats. Oncol Rep 2001, eight:1341?345. Kubo N, Myojin Y, Shimamoto F, Kashimoto N, Kyo E, Kamiya K, Watanabe H: Protective effects of a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia and Agaricus blazei murill against X-irradiation in B6C3F1 mice: improved compact intestinal crypt survival and prolongation of average time for you to animal. Int.
