Product Name :
Munc13-4 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
FHL 3 antibody FHL3 antibody FLJ00067 antibody HLH 3 antibody HLH3 antibody HPLH 3 antibody HPLH3 antibody Jinx antibody Munc13 4 antibody Munc13-4 antibody 展开
Function :
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca2+-dependent secretory lysosome exocytosis in mast cells.Expressed at high levels in spleen, thymus and leukocytes. Also expressed in lung and placenta, and at very low levels in brain, heart, skeletal muscle and kidney. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Recombinant protein within human Munc13-4 aa 900-1090.
Species reactivity:
Human, Rat
Verify application:
WB, IF-Cell, IHC-P
Coupling :
unconjugated
Clone number:
RRID:
AB_3071152
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.1427158-38-0 manufacturer Aliquot store at -20℃.4,6-Dichloropyrimidin-5-ol Order Avoid repeated freeze / thaw cycles.PMID:33580386
Storage buffer solution:
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
123 kDa
Positive control :
Jurkat cell lysate, K562 cell lysate, rat lung tissue lysate, Hela, SHSY5Y, rat spleen tissue, human placenta tissue.