Product Name :
NEFM Recombinant Rabbit Monoclonal Antibody [JM11-20]
Predicted band size :
Observed band size :
Synonyms:
150kDa medium antibody NEF3 antibody NEFM antibody Neurofilament 3 antibody NF160 antibody NFM antibody
Function :
Neurofilament-M (NF-M), for neurofilament medium polypeptide, a member of the intermediate filament family, is a major component of neuronal cytoskeletons. Neurofilaments are dynamic structures; they contain phosphorylation sites for a large number of protein kinases, including protein kinase A, protein kinase C, cyclin-dependent kinase 5, extracellular signal regulated kinase, glycogen synthase kinase-3, and stress-activated protein kinase gamma.2,2-Bis(bromomethyl)-1,3-dioxolane Data Sheet In addition to their role in the control of axon caliber, neurofilaments may affect other cytoskeletal elements, such as microtubules and actin filaments. Changes in neurofilament phosphorylation or metabolism are frequently observed in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson’s disease, and Alzheimer’s disease.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human NEFM aa 651-692 / 916.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IF-Tissue, IHC-P, IP
Coupling :
unconjugated
Clone number:
JM11-20
RRID:
AB_3070413
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.847795-98-6 supplier 4), 0.PMID:33507232 05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 102 kDa
Positive control :
293T cell lysates, N2A, PC-12, SH-SY5Y, mouse brain tissue, rat brain tissue, human brain tissue.