Product Name :
Nudel Recombinant Rabbit Monoclonal Antibody [JG38-63]
Predicted band size :
38 kDa
Observed band size :
40 kDa
Synonyms:
A. nidulans antibody DKFZp451M0318 antibody ENDOOLIGOPEPTIDASE A antibody EOPA antibody MITAP 1 antibody MITAP1 antibody Mitosin associated protein 1 antibody Mitosin associated protein MITAP1 antibody Mitosin-associated protein 1 antibody Ndel 1 antibody 展开
Function :
NudE-like protein (Ndel1) is expressed in the testis, brain, heart, hypothalamus, liver, lung, spleen, and stomach, specifically in the interphase centrosome and mitotic spindle. It positively regulates minus-end directed dynein. Evidence suggests that Ndel1 interacts with LIS1 to sustain the function of dynein, thereby impacting microtubule organization, nuclear translocation, and neuronal positioning. Ndel1 is phosphorylated during mitosis and seems to tether dynactin and dynein to the mother centriole for microtubule anchoring. Loss of function of Ndel1 in the developing neocortex impairs neuronal positioning and uncouples the centrosome and nucleus. Ndel1 may also impair mitochondrial transport or function, initiating a cascade of events culminating in psychiatric illness such as lissencephaly and schizophrenia.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human Nudel aa 1-49 / 345.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P
Coupling :
unconjugated
Clone number:
JG38-63
RRID:
AB_3070868
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Formula of 945459-80-3 Aliquot store at -20℃.2-(Azepan-1-yl)ethan-1-amine supplier Avoid repeated freeze / thaw cycles.PMID:33600884
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
38 kDa
Positive control :
Rat brain tissue lysates, human liver cancer tissue, human small intestine tissue, human uterus tissue.