Product Name :
NUR77 Recombinant Rabbit Monoclonal Antibody [JM59-11]
Predicted band size :
64 kDa
Observed band size :
64 kDa
Synonyms:
Early response protein NAK1 antibody GFRP 1 antibody GFRP antibody GFRP1 antibody Growth factor inducible nuclear protein N10 antibody Growth Factor Inducible Nuclear Protein NP10 antibody Growth Factor Response Protein 1 antibody Hbr1 antibody HMR antibody Hormone Receptor antibody 展开
Function :
Nurr1 (Nur-related factor 1) and Nur77 (also designated NGFI-B) encode orphan nuclear receptors which may comprise an additional subfamily within the nuclear receptor superfamily.2-(Tributylstannyl)thiophene Chemical name The rat and human homologs of mouse Nurr1 are designated RNR1 and NOT, respectively. Both Nurr1 and Nur77 are growth factor inducible immediate early response genes. Induction of both Nurr1 and Nur77 is seen after membrane depolarization while only Nur77 induction is seen with NGF stimulation. JunD acts as a mediator for Nur77. An increase in Nur77 expression is seen in activated T cells during G0 to G1 transition and throughout the G1 phase. In addition to its function as an immediate early gene, Nur77 may play a role in TCR-mediated apoptosis. Cyclosporin A, a potent immunosuppressant, has been shown to inhibit the ability of Nur77 to bind DNA. A dominant negative form of Nur77 can protect T cell hybridomas from activation-induced apoptosis.56074-21-6 manufacturer However, the absolute requirement of Nur77 for TCR-mediated apoptosis is still under debate.PMID:33494635
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human NUR77 aa 10-49 / 598.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IF-Tissue, IHC-P, FC
Coupling :
unconjugated
Clone number:
JM59-11
RRID:
AB_3070451
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 64 kDa
Positive control :
Rat brain tissue lysates, HepG2, Hela, NIH/3T3, human liver tissue, human colon carcinoma tissue, human breast tissue, mouse testis tissue, mouse ovarian tissue.